Ondansetron is the active substance in an antiemetic drug known commercially as Vonau.This oral and injectable medicinal product is indicated for the treatment and prevention of nausea and vomiting, as its action blocks the reflection of vomiting, reducing the feeling of nausea.
Vonau flash is available as 4 mg and 8 mg tablets, which contain ondansetron in its composition that acts to prevent and treat nausea and vomiting in adults and children over 2 years of age.
- Injectable Vonau is available at the same doses as ondansetron and is indicated for the control of nausea and vomiting induced by chemotherapy and radiation therapy in adults and children from 6 months.
- In addition.
- It is also indicated for the prevention and treatment of nausea and vomiting in the postoperative.
- In adults and children from 1 month.
The tablet should be removed from the package and placed immediately on the tip of the tongue so that it dissolves in seconds and swallows, without the need to drink the medicine with liquids.
Prevention of nausea and vomiting in general
Adults: The recommended dose is 2 tablets of 8 mg.
Children over 11 years of age: the recommended dose is 1 to 2 tablets per 4 mg.
Children 2 to 11 years old: the recommended dose is 1 tablet to 4 mg
Prevention of postoperative nausea and vomiting:
The dose to be used should be as described above for each age and should be taken 1 hour before inducing anesthesia.
Prevention of nausea and vomiting in general associated with chemotherapy:
For chemotherapy that causes severe vomiting, the recommended dose is 24 mg of Vonau in a single dose, equivalent to 3 tablets to 8 mg, 30 minutes before the start of chemotherapy.
For chemotherapy that causes moderate vomiting, the recommended dose is 8 mg of ondansetron, twice daily, while the first dose should be given 30 minutes before chemotherapy and the second dose 8 hours later.
For one or two days after the end of chemotherapy, it is recommended to take 8 mg of ondansetron, twice daily every 12 hours.
For children 11 years and older, the same dose is recommended for adults and children 2 to 11 years of age, 4 mg of ondansetron is recommended 3 times a day for 1 or 2 days after the end of chemotherapy.
Prevention of nausea and vomiting associated with radiation therapy
For total irradiation of the body, the recommended dose is 8 mg of ondansetron, 1 to 2 hours before each fraction of radiation therapy applied each day.
For radiation therapy of the abdomen in a single high dose, the recommended dose is 8 mg of ondansetron, 1 to 2 hours before radiation therapy, with subsequent doses every 8 hours after the first dose, for 1 to 2 days after the end of radiation therapy..
For radiation therapy of the abdomen in fractional daily doses, the recommended dose is 8 mg of ondansetron, 1 to 2 hours before radiation therapy, with subsequent doses every 8 hours after the first dose, each day of application of radiation therapy.
For children 2 to 11 years old, a dose of 4 mg of ondansetron is recommended 3 times daily, the first should be administered 1 to 2 hours before the start of radiation therapy, with subsequent doses every 8 hours after the first dose.It is recommended to administer 4 mg of ondansetron, 3 times a day for 1 to 2 days after the end of radiation therapy.
Injectable Vonau should be administered by a health care professional and the choice of dosage regimen should be determined according to the severity of nausea and vomiting.
Adults: The recommended intravenous or intramuscular dose is 8 mg, administered immediately prior to treatment.
Children and adolescents 6 months to 17 years: The dose for nausea and vomiting induced by chemotherapy can be calculated based on body surface area or weight.
This dose may be modified by your doctor, depending on the severity of the situation.
This medicinal product should not be used by people allergic to the active substance or any of the components contained in the formula, in pregnant or nursing women and in children under 2 years of age.
The use of ondansetron should also be avoided in patients with congenital long QT syndrome and used with caution in people with kidney or liver problems.In addition, Vonau, whose presentation is on tablets, should be used with caution in phenylketonurates due to the excipients it contains.in the formula.
The most common side effects that occur with the use of Vonau flash pills are diarrhea, constipation, headaches and fatigue.
Less and less frequently, discomfort and sores may also occur. If symptoms such as discomfort, restlessness, redness of the face, palpitations, itching, pulse in the ear, cough, sneezing, shortness of breath within the first 15 minutes of administration of the medicine, it is necessary to consult an emergency doctor.
The most common side effects that can occur when using injectable Vonau are a feeling of heat or redness, constipation and reactions at the site of intravenous injection.
Less commonly seizures, movement disorders, arrhythmias, chest pain, decreased heart rate, hypotension, hiccups, asymptomatic increase in liver functional tests, allergic reactions, dizziness, transient visual disturbances, longer QT interval, transient blindness and toxic rash.