Trimetazidine is an active substance indicated for the treatment of ischemic heart failure and ischemic heart disease, which is a disease caused by lack of blood flow in the arteries.
Trimmetazidine can be purchased at a pharmacy for a price of approximately R $ 45-107, upon presentation of a prescription.
- The recommended dose is 1 tablet at 35 mg.
- Twice daily.
- Once in the morning.
- At breakfast and once at night.
- During dinner.
Trimetazidine preserves the energy metabolism of ischemic cells, exposed to a low concentration of oxygen, avoiding the decrease of intracellular levels of ATP (energy), thus ensuring the proper functioning of ion pumps and transmembrane flow of sodium and potassium, while maintaining the cell.Homeostasis.
This preservation of energy metabolism is achieved by inhibiting the alpha-oxidation of fatty acids, exercised by trimmetazidine, which increases glucose oxidation, which is a way to obtain an energy that requires less oxygen consumption compared to the process of beta-oxidation.Thus, the boosting of glucose oxidation optimizes the cellular energy process, maintaining the proper energy metabolism during ischemia.
In patients with ischemic heart disease, trimetazidine acts as a metabolic agent while preserving high levels of intracellular myocardial phosphate.
This medicine is counterinditive in patients with hypersensitivity to trimetazidine or any of the ingredients of the formula, people with Parkinson’s disease, symptoms of parkinsonism, tremors, restless legs syndrome and other changes related to movement and severe renal impairment with clearance less than 30 ml / min.
In addition, this medicine should not be used by children under 18 years of age, pregnant or lactating women.
Some of the most common side effects that can occur during treatment with trimetazidine are dizziness, headache, abdominal pain, diarrhea, poor digestion, nausea, vomiting, rashes, itching, hives and weakness.