Canals, also known as paramesonefrious channels, are structures present in the embryo that give rise to female internal genitalia, either child or remain in its vestigial form, if it is a child.
In women, Muller’s canals come from the uterine tubes, uterus and upper vagina, and in men, the structures that give birth to male sex organs such as the epididymis, the deferential canal and semi-critical vesicles are Wolff’s channels, which in women remain vestigially.
Muller channels and Wolff channels depend on hormonal controls
In the embryo that will give birth to the male sex, a hormone, called anti-muller hormone, is produced, which leads to the regression of Muller’s ducts, then testosterone is produced, which is released by the testes, which will stimulate differentiation of Wolff channels.
In the absence of the production of these hormones, in the female embryo, Muller channels develop, leading to differentiation and formation of female internal genitalia.
Some complications can occur when differentiating Mullérian channels, which can cause abnormalities:
This syndrome is characterized by the absence of uterus, uterine tubes and upper vagina, however, secondary sexual traits develop there because the ovaries are always present as they do not depend on Muller’s ducts to develop.
Urinary system and spine abnormalities may also occur.It is not yet known exactly what causes this syndrome, usually discovered in adolescence, due to the absence of menstruation.Learn more about this syndrome, what your symptoms are, and how to treat it.
This anomaly is thought to develop due to a problem with the development of one of Muller’s ducts.The unicorn’s uterus is about half the size of a normal uterus and has only one uterine tube, which can make pregnancy difficult.
When lateral fusion problems occur, a blockage of the cervix or vagina can occur, which can lead to menstrual cramping or endometriosis in adulthood.In these cases, obstructive removal of the vaginal septum may be necessary.
When non-obstructive lateral fusion problems occur, the formation of a bicorn or split uterus can occur, which can make pregnancy difficult, lead to preterm births, cause miscarriages, or even cause infertility.
Obstructive vertical fusion problems can also occur, which can result in the absence of a vagina, but the presence of a uterus, and may need to be removed if the cervix is not present.