Sodium metamyzole or dipyrone is an analgesic, antipyretic and spasmolytic drug used in the treatment of pain and diseases, usually caused by diseases such as flu and colds.
Dipirona can be purchased from conventional pharmacies under the trade name Neo-Melubrina, Novalcin, Novalcin, Apiron, Prodoline, Messelfenil, Dalmasin, Conmel, among others, can be obtained in different presentations: drops, tablets, bottle, suppository or injectable. Solution.
- Dipirone is indicated for the treatment of pain and the child.
- Analgesic and antipyretic effects can be observed within 30 to 60 minutes of administration and usually for approximately 4 hours.
How dipirone is used usually depends on the pharmaceutical form in which it is used:
The recommended dose for adults and adolescents over 15 years of age is 1 to 2 tablets of 500 mg or 1 tablet of 1000 mg up to 4 times daily. This medicine should not be chewed.
The tablet should be dissolved in 1/2 cup of water and taken immediately after diluting the hair. The recommended dose is 1 tablet up to 4 times a day.
The recommended dosage for adults and adolescents over 15 years of age is 20 to 40 drops in a single dose or up to a maximum of 40 drops, 4 times a day. For children, records should be adapted to weight and age, according to the Table below:
Children under 3 months weighing less than 5 kg should not be treated with dipirone.
The recommended dose for adults and adolescents over 15 years of age is 10 to 20 ml, in a single dose up to a maximum of 20 ml, 4 times daily. For children, doses should be administered according to weight and age, according to the table below:
5 to 8 kg (3 to 11 months)
Unique doses
Maximum dose
1. 25 to 2. 5
10 (4 doses x 2. 5 ml)
Unique doses
Maximum dose
3. 75 to 7. 5
30 (4 doses x 7. 5 ml)
Unique doses
Maximum dose
7. 5 to 15
60 (4 doses x 15 ml)
Unique doses
Maximum dose
8. 75 to 17. 5
70 (4 doses x 17. 5 ml)
Children under 3 months weighing less than 5 kg should not be treated with dipirone.
Suppositoriums should be applied rectally as follows
The recommended dose is 1 suppository, up to 4 times a day. If the effect of a single dose is not sufficient after the analgesic effect has been reduced, the dose may be repeated according to the dose and the maximum daily dose.
Injectable dipirone can be administered intravenously or intramuscularly, with the person attached and under medical supervision. In addition, intravenous administration should be very slow, at an infusion rate of no more than 50 mg dipirone per minute, to prevent tension from dropping.
The recommended dose for adults and adolescents over 15 years of age is 2 to 5 ml in a single dose, up to a maximum daily dose of 10 ml. In infants and children, the recommended dose depends on the weight as shown in the table below. :
If parenteral administration of dipirone is considered in infants 5 to 8 kg, it should only be used intramuscularly.
Dipyrone is a substance with analgesic, antipyretic and spasmolytic effects, which is activated only when ingested and metabolized by the body.
Some studies suggest that the active metabolites of dipirone act and act by inhibiting cyclooxygenase enzymes (COX-1, COX-2 and COX-3), inhibiting the synthesis of prostaglandins, preferably in the central nervous system and desensitizing peripheral pain receptors, implying activity through nitric oxide-cGMP in the pain receptor.
Side effects of Dipirona include hives, hypotension and a severe allergic reaction.
Dipirone is contraindicated during transport, lactation and in patients allergic to sodium dipirone or any of the components of the formula, asthma, congenital glucose-6-phosphate-dehydrogenase deficiency, bone marrow suppression and blood dysrasia.
Patients who have developed bronchospasm or other allergic reactions with painkillers such as salicylates, acetaminophen, diclofenac, ibuprofen, indomethacin and naproxen, as well as taking dipirone sodium.