Poiquilocytosis is a term that can appear in the blood formula and means an increase in the number of circulating poiquiocytes in the blood, which are hematitis that may have an abnormal form. Erythrocytes are rounded, boring and have a clearer central region due to the distribution of hemoglobin. Thanks to changes in the membrane of erythrocytes, their shape can be modified, causing hematitis in different ways in the bloodstream, which could interfere with their function.
The main poiquiocytes identified in microscopic blood evaluation in blood cells, dacriocytes, elipocytes and codocytes, as they appear in anemias; therefore, its identification is important so that the differentiation between anemias can be established, allowing the diagnosis and initiation of the most appropriate treatment.
Poiquiocytes can be seen under the microscope from the functioning of a blood vessel, if:
The report of the blood count, if a poiquitocytosis is determined during the microscopic examination, the presence of the identified poichilocycocyte is indicated. Identification of poiquiocytes is important for the doctor to know the general condition of the person and, depending on the change observed, may indicate further testing to complete the diagnosis and begin immediate treatment.
Poiquiocytes occur as a result of changes related to erythrocytes, such as biochemical changes in the membrane of these cells, metabolic changes in enzymes, haemoglobin-related abnormalities and aging of hematitis; these alterations can occur in various diseases, resulting in poiquilocytosis, with the main situations being:
Sickle cell anemia is a disease characterized mainly by an alteration in the form of hematitis, which resembles a form similar to that of man (sickle cell disease), due to the mutation of one of the cells that form hemoglobin, which decreases the ability of hemoglobin to reach oxygen and therefore , transport to organisms and tissues, and increases the difficulty for red blood cells to pass through the veins.
Due to this alteration and reduction of oxygen transport, the person feels excessively tired, has widespread pain, paleness and stunted growth, for example.
In some cases, although sickle cell disease is characteristic of sickle cell disease, it is also possible to observe the presence of codocytes.
Myelofibrosis is a type of myelorolerative neoplasm that has the characteristic presence of circulating dacriocytes in peripheral blood, usually the presence of these dacriocytes indicates that there are changes in the bone marrow, which occurs in myelofibrosis.
This type of neoplasm is characterized by the presence of mutations that promote changes in the process of cell production in the bone marrow, allowing an increase in the number of mature cells at this site, which promote the formation of scarring in the bone marrow, decreasing to function over time.
Hemolytic anemias are characterized by the production of antibodies that react against erythrocytes, favoring their destruction and causing the appearance of anemia symptoms, such as fatigue, paleness, browning, and weakness, for example. As a consequence of the destruction of erythrocytes, there is an increase in the production of blood cells by the bone marrow and blood, which could lead to the production of abnormal hematitis, such as spherocytes and lipocytes. Know more about hemolytic anemia.
Diseases affecting the liver can also cause poiquiocytes, mainly stomatocytes and acantocytes, if more tests are needed to evaluate liver activity and, if possible, diagnose any alterations.
Hierarchical deficiency anemia, also known as ferropenic anemia, is characterized by a decrease in the amount of hemoglobin circulating in the body and therefore oxygen; they are because hierarchy is important for the formation of hemoglobin, in this way signs and symptoms appear such as weakness, fatigue, discouragement and fainting, the diffusion of the circulating hierarchy can also favor the appearance of poiquilocytes, mainly codocytes. iron deficiency anemia.