Platelets are fragments of small cells derived from a cell produced by the bone marrow, the megacarocyte.The process of production of megakaryocytes by fragmentation of bone marrow and platelets lasts about 10 days and is regulated by the hormone thrombopoietin, which is produced by the liver and platelets.Kidneys
Platelets play a key role in the platelet cap formation process, which is critical to preventing significant bleeding, so it is important that the amount of platelets circulating in the body is within normal reference values.
- Platelets are essential for the platelet cap formation process during the normal response to a vascular injury.
- In the absence of platelets.
- Several spontaneous blood leaks can occur in the small vessels.
- Which can compromise a person’s health.
Platelet function can be classified into three main stages, which are adhesion, aggregation and release, and are mediated by factors released by platelets during the process, as well as by other factors produced by the blood and body.platelets are immobilized at the site of the injury to prevent excessive bleeding.
At the site of the lesion, there is a specific interaction between platelets and the cell wall, the adhesion process and the interaction between platelets and platelets (aggregation processes), which are mediated by the fact that Von Willebrand can be found within platelets.In addition to the release of the Von Willebrand factor, there is the production and activity of other factors and proteins related to the blood clotting process.
Von Willebrand factor present in platelets is normally associated with coagulation factor VIII, which is important for the activation of factor X and the continuation of the coagulation cascade, resulting in the production of fibrin, which corresponds to the buffer secondary hemostatic.
For the coagulation cascade and platelet cap formation to develop correctly, the amount of platelets in the blood must be between 150,000 and 450,000/mm3 of blood; however, some situations can cause a decrease or increase in the amount of platelets in the blood..
Thrombocytosis, which corresponds to an increase in the number of platelets, generally does not generate symptoms, it is perceived through the performance of the blood formula The increase in the platelet count is generally related to changes in the bone marrow, myeloperative diseases, anemia haemolytic and after surgery, for example, while the body tries to prevent major bleeding. Learn about other causes of platelet growth.
Thrombopenia is characterized by a decrease in the amount of platelets that can be caused by autoimmune diseases, infectious diseases, nutritional deficiency of iron, folic acid or vitamin B12, and problems related to problems related to spleen problems, for example.you may notice certain symptoms, such as bleeding in the nose and gums, increased menstrual flow, the presence of purple spots on the skin, and the presence of blood in the urine, for example.Learn all about thrombocytopenia.
A possible alternative to increase platelet production is the hormone replacement of thrombopoietin, as this hormone is responsible for stimulating the production of these cell fragments, however, this hormone is not available for clinical use, however there are drugs that mimic the function of this hormone.they can increase platelet production approximately 6 days after initiation of treatment, such as Romiplostim and Eltrombopag, which should be used in accordance with medical advice.
However, it is recommended to use medicines only after identifying the cause of platelet decline, and it may be necessary to remove the spleen, use corticosteroids, antibiotics, blood filtration or even a platelet transfusion.It is also important to have a proper and balanced diet, rich in cereals, fruits, vegetables, vegetables and lean meats to help the process of blood cell formation and promote the recovery of the body.
Platelet donation can be done by anyone who weighs more than 50 kg, is healthy, and aims to help recovery of the person being treated for leukemia or other cancers, people who undergo bone marrow transplants, and heart surgery, for example.
Platelet donation can be done without harming the donor, as the replacement of platelets by the organism takes about 48 hours and is made from the total blood draw of the donor which passes immediately through a centrifugation process, until a separation of blood occurs During the centrifugation process, the platelets are separated into a special collection bag which immediately goes through a centrifugation process, until a separation of blood occurs During the centrifugation process, the platelets are separated into a special collection bag , while the other blood components return to the donor’s bloodstream.
The process takes about 90 minutes and an anticoagulant solution is used throughout the process to avoid clots and preserve blood cells. Platelet donation is only allowed for women who have never been pregnant and for people who have not used aspirin, aspirin, aspirin or non-hormonal drugs.anti-inflammatory drugs within 3 days of donation.