Paramiloidosis, also known as foot disease or familial amyloid polyneuropathy, is a rare incurable disease of genetic origin, characterized by the production of amyloid fibers by the liver, which settle into tissues and nerves, slowly destroying them.
This disease is called foot disease because it is in the feet where symptoms first appear and gradually appear in other areas of the body.
- In paramilosa.
- An alteration of the peripheral nerves causes damage to the areas inerved by these nerves.
- Causing changes in sensitivity to heat.
- Cold.
- Pain.
- Touch and vibration; In addition.
- Motor capacity is also affected and muscles lose muscle mass.
- Suffering due to great atrophy and loss of strength.
- Resulting in difficulty walking and using limbs.
Paramilosa affects the peripheral nervous system and produces
In addition, in the terminal stage of the disease, the person may suffer from reduced mobility, need a wheelchair or remain bedridden.
The disease usually occurs between the ages of 20 and 40, causing death 10 to 15 years after the onset of the first symptoms.
Paramilosa is an autosomal dominant inherited disease that does not heal and is caused by a genetic mutation in the TTR protein, which consists of the deposit into tissues and nerves of a fibrillary substance produced by the liver, called amyloid.
The deposit of this substance in tissues leads to a gradual decrease in sensitivity to stimuli and motor capacity.
The most effective treatment for paramily is liver transplantation, which can slow the progression of the disease somewhat.The use of immunosuppressive drugs is indicated to prevent the individual’s body from rejecting the new organ, but unpleasant side effects may occur.
In addition, your doctor may also recommend a medicine, called Tafamidis, that helps slow the progression of the disease.