Methotrexate is a drug similar to folic acid and is indicated for the treatment of rheumatoid arthritis and severe psoriasis that does not respond to other treatments; however, in injectable form, it can be used in chemotherapy to treat cancer.
This drug is available as an injectable tablet and can be found in pharmacies with the names Trixilem and Metrex, for example.
- Methotrexate tablets are indicated for the treatment of rheumatoid arthritis because it has effects on the immune system that reduce inflammation.
- And their action is noticeable after the 3rd week of treatment.
- In contrast.
- In the treatment of psoriasis.
- Methotrexate decreases the proliferation and inflammation of skin cells.
- And effects are observed 1 to 4 weeks after starting treatment.
Injectable methotrexate is indicated to treat severe psoriasis and the following cancers:
The dose varied depending on the disease to be treated, so
The recommended oral dose may be 7. 5 mg, once a week; or 2. 5 mg every 12 hours, in three intakes, should be cycled once a week.
The doses of each regimen should be adjusted gradually to achieve a good response, but should not exceed a total weekly dose of 20 mg.
The recommended oral dose is 10 to 25 mg per week up to an appropriate response, alternating 2. 5 mg every 12 hours, in three doses.
The doses of each diet can be gradually adjusted to achieve a good clinical result, avoiding exceeding 30 mg per week.
For cases of severe psoriasis, injectable methotrexate is used, a single dose of 10 to 25 mg per week should be administered until an adequate response is obtained.
The therapeutic dose range of methotrexate for indications in cancer is very wide and depends on the type of cancer, body weight and condition of the patient.
The most common side effects that can occur during treatment with methotrexate tablets are: severe headaches, stiff neck, vomiting, stiffness, skin hypertrophy, increased uric acid and reduced sperm count, appearance of mouth ulcers, inflammation of the tongue and spine, diarrhea, decreased white blood cell and platelet content , renal failure and pharyngitis.
Methotrexate tablets is an contraption in patients allergic to methotrexate or any of the ingredients of the formula, pregnant women, breastfeeding women, people with weakened immune systems, severe renal or hepatic impairment and changes in blood cells, such as a reduced blood content. red blood cells and platelets.